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Development of a new method for RMR and Q classification method to optimize support system in tunneling

Asghar RAHMATI,Lohrasb FARAMARZI,Manouchehr SANEI

《结构与土木工程前沿（英文）》 2014年第8卷第4期页码 448-455 doi: 10.1007/s11709-014-0262-x

摘要： Rock mass classification system is very suitable for various engineering design and stability analysis. classification method is confirmed by Japan Highway Public Corporation that this method can figure out either strength or deformability of rock mass, further appropriating the amount of rock bolts, thickness of shotcrete, and size of pitch of steel ribs just after the blasting procedure. Based on these advantages of method, in this study, according to data of five deep and long tunnels in Iran, two equations for estimating the value of method from and classification systems were developed. These equations as a new method were able to optimize the support system for and classification systems. From classification and its application in these case studies, it is pointed out that the method for the design of support systems in underground working is more reliable than the and classification systems.

关键词： JH classification Q and RMR classification new method

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An approach for evaluating fire resistance of high strength Q460 steel columns

Wei-Yong WANG, Guo-Qiang LI, Bao-lin YU

《结构与土木工程前沿（英文）》 2014年第8卷第1期页码 26-35 doi: 10.1007/s11709-014-0239-9

摘要： To develop a methodology for evaluating fire resistance of high strength Q460 steel columns, the load bearing capacity of high strength Q460 steel columns is investigated. The current approach of evaluating load bearing capacity of mild steel columns at room temperature is extended to high strength Q460 steel columns with due consideration to high temperature properties of high strength Q460 steel. The critical temperature of high strength Q460 steel column is presented and compared with mild steel columns. The proposed approach was validated by comparing the predicted load capacity with that evaluated through finite element analysis and test results. In addition, parametric studies were carried out by employing the proposed approach to study the effect of residual stress and geometrical imperfections. Results from parametric studies show that, only for a long column (slenderness higher than 75), the magnitude and distribution mode of residual stress have little influence on ultimate load bearing capacity of high strength Q460 steel columns, but the geometrical imperfections have significant influence on any columns. At a certain slenderness ratio, the stability factor first decreases and then increases with temperature rise.

关键词： high strength Q460 steel load bearing capacity temperature

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R158Q and G212S, novel pathogenic compound heterozygous variants in of Gitelman syndrome

《医学前沿（英文）》 2022年第16卷第6期页码 932-945 doi: 10.1007/s11684-022-0963-9

摘要： The dysfunction of Na⁺-Cl⁻ cotransporter (NCC) caused by mutations in solute carrier family12, member 3 gene (SLC12A3) primarily causes Gitelman syndrome (GS). In identifying the pathogenicity of R158Q and G212S variants of SLC12A3, we evaluated the pathogenicity by bioinformatic, expression, and localization analysis of two variants from a patient in our cohort. The prediction of mutant protein showed that p.R158Q and p.G212S could alter protein’s three-dimensional structure. Western blot showed a decrease of mutant Ncc. Immunofluorescence of the two mutations revealed a diffuse positive staining below the plasma membrane. Meanwhile, we conducted a compound heterozygous model—Ncc R156Q/G210S mice corresponding to human NCC R158Q/G212S. Ncc^R156Q/G210S mice clearly exhibited typical GS features, including hypokalemia, hypomagnesemia, and increased fractional excretion of K⁺ and Mg²⁺ with a normal blood pressure level, which made Ncc^R156Q/G210S mice an optimal mouse model for further study of GS. A dramatic decrease and abnormal localization of the mutant Ncc in distal convoluted tubules contributed to the phenotype. The hydrochlorothiazide test showed a loss of function of mutant Ncc in Ncc^R156Q/G210S mice. These findings indicated that R158Q and G212S variants of SLC12A3 were pathogenic variants of GS.

关键词： Gitelman syndrome mouse model compound heterozygous hypokalemia Slc12a3

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Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

null

《医学前沿（英文）》 2018年第12卷第2期页码 229-235 doi: 10.1007/s11684-017-0581-0

摘要：

On May 23, 2017, the US Food and Drug Administration (FDA) approved a treatment for cancer patients with positive microsatellite instability-high (MSI-H) markers or mismatch repair deficient (dMMR) markers. This approach is the first approved tumor treatment using a common biomarker rather than specified tumor locations in the body. FDA previously approved Keytruda for treatment of several types of malignancies, such as metastatic melanoma, metastatic non-small-cell lung cancer, recurrent or metastatic head and neck cancer, refractory Hodgkin lymphoma, and urothelial carcinoma, all of which carry positive programmed death-1/programmed death-ligand 1 biomarkers. Therefore, indications of Keytruda significantly expanded. Several types of malignancies are disclosed by MSI-H status due to dMMR and characterized by increased neoantigen load, which elicits intense host immune response in tumor microenvironment, including portions of colorectal and gastric carcinomas. Currently, biomarker-based patient selection remains a challenge. Pathologists play important roles in evaluating histology and biomarker results and establishing detection methods. Taking gastric cancer as an example, its molecular classification is built on genome abnormalities, but it lacks acceptable clinical characteristics. Pathologists are expected to act as “genetic interpreters” or “genetic translators” and build a link between molecular subtypes with tumor histological features. Subsequently, by using their findings, oncologists will carry out targeted therapy based on molecular classification.

关键词： molecular classification precision medicine pembrolizumab PD-1/PD-L1 MSI-H

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GC/LC-Q-TOFMS 两种技术联用同时筛查水果蔬菜中733 种农药残留 Article

庞国芳, 常巧英, 白若镔, 范春林, 张紫娟, 闫宏远, 吴兴强

《工程（英文）》 2020年第6卷第4期页码 432-441 doi: 10.1016/j.eng.2019.08.008

摘要：

本文通过创建LC-Q-TOFMS（525种农药）和GC-Q-TOFMS（485种农药和209种PCBs）两大精确质谱数数据库，开发了一次样品制备、两种高分辨质谱联用同时检测733种农药化学污染物残留的检测方法通过8种代表性水果蔬菜对联用技术的筛查农药范围、灵敏度、回收率和重现性等方法效能评价，显示出这项联用技术有三方面优势：①两种技术联用与单种技术相比，其发现能力分别提高了51.1%（GC-Q-TOFMS，485种）和39.6%（LC-Q-TOFMS，525种）；②联用技术能够满足78%的农药筛查限（SDL）低于10 μg·kg^–1，满足国际&ldquo

关键词：农药残留 GC-Q-TOFMS LC-Q-TOFMS 精确质量数据库谱图库水果蔬菜

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新型电光调Q腔内倍频绿光激光器

陈飞,霍玉晶,何淑芳,冯立春

《中国工程科学》 2000年第2卷第4期页码 39-42

摘要：

本文报道了一种新型的LD泵浦Nd:YVO₄-KTP电光调Q绿光激光器，用单块KTP晶体同时作为电光调Q开关和Ⅱ类相位匹配的倍频晶体，减少了腔内损耗，提高了效率，得到了脉宽为12ns

关键词： KTP 绿光激光器电光调Q开关倍频

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An approach for mechanical fault classification based on generalized discriminant analysis

LI Wei-hua, SHI Tie-lin, YANG Shu-zi

《机械工程前沿（英文）》 2006年第1卷第3期页码 292-298 doi: 10.1007/s11465-006-0022-2

摘要： To deal with pattern classification of complicated mechanical faults, an approach to multi-faults classification based on generalized discriminant analysis is presented. Compared with linear discriminant analysis (LDA), generalized discriminant analysis (GDA), one of nonlinear discriminant analysis methods, is more suitable for classifying the linear non-separable problem. The connection and difference between KPCA (Kernel Principal Component Analysis) and GDA is discussed. KPCA is good at detection of machine abnormality while GDA performs well in multi-faults classification based on the collection of historical faults symptoms. When the proposed method is applied to air compressor condition classification and gear fault classification, an excellent performance in complicated multi-faults classification is presented.

关键词： generalized discriminant non-separable abnormality classification multi-faults classification

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EAI-oriented information classification code system in manufacturing enterprises

WANG Junbiao, DENG Hu, JIANG Jianjun, YANG Binghong, WANG Bailing

《机械工程前沿（英文）》 2008年第3卷第1期页码 81-85 doi: 10.1007/s11465-008-0011-8

摘要： Although the traditional information classification coding system in manufacturing enterprises (MEs) emphasizes the construction of code standards, it lacks the management of the code creation, code data transmission and so on. According to the demands of enterprise application integration (EAI) in manufacturing enterprises, an enterprise application integration oriented information classification code system (EAIO-ICCS) is proposed. EAIO-ICCS expands the connotation of the information classification code system and assures the identity of the codes in manufacturing enterprises with unified management of codes at the view of its lifecycle.

关键词： EAI EAIO-ICCS management classification connotation

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Q&P 工艺理念在热轧先进高强度钢中的应用研究

袁国,康健,张贺,李云杰,胡虹玲,王国栋

《中国工程科学》 2014年第16卷第1期页码 59-65

摘要：

为满足汽车工业轻量化发展要求，以Q&P（quenching & partitioning）工艺为基础的先进高强度钢受到了广泛关注，为使其在普通热连轧生产线上实现工业化并广泛应用，本文对Q&P理念在热轧工艺中的应用进行了基础研究。结果表明在传统热处理Q&P工艺中引入热变形处理后，组织细化显著，并获得了一定量的残余奥氏体。实验钢在保持较高强度的同时获得了较大的强塑积，结合目前国内热连轧生产线以超快冷系统为核心的新一代控轧控冷（TMCP）技术的应用，确定了在热连轧生产线生产热轧Q&P钢（DQ（direct quenching

关键词：先进高强度钢 Q&P DQ&P 热轧残余奥氏体

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Fault classification and reconfiguration of distribution systems using equivalent capacity margin method

K. Sathish KUMAR, T. JAYABARATHI

《能源前沿（英文）》 2012年第6卷第4期页码 394-402 doi: 10.1007/s11708-012-0211-0

摘要： This paper investigates the capability of support vector machines (SVM) for prediction of fault classification and the use of the concept of equivalent capacity margin (ECM) for restoration of the power system. The SVM, as a novel type of machine learning based on statistical learning theory, achieves good generalization ability by adopting a structural risk minimization (SRM) induction principle aimed at minimizing a bound on the generalization error of a model rather than the minimization of the error on the training data only. Here, the SVM has been used as a classification. The inputs of the SVM model are power and voltage values. An equation has been developed for the prediction of the fault in the power system based on the developed SVM model. The next steps of this paper are the restoration and reconfiguration by using the ECM concept, the development of a code, and the testing of the results with various load outages, which have been executed for a 12 load system.

关键词： support vector machines (SVM) structural risk minimization (SRM) equivalent capacity margin (ECM) restoration fault classification

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Progress on molecular biomarkers and classification of malignant gliomas

null

《医学前沿（英文）》 2013年第7卷第2期页码 150-156 doi: 10.1007/s11684-013-0267-1

摘要：

Gliomas are the most common primary intracranial tumors in adults. Anaplastic gliomas (WHO grade III) and glioblastomas (WHO grade IV) represent the major groups of malignant gliomas in the brain. Several diagnostic, predictive, and prognostic biomarkers for malignant gliomas have been reported over the last few decades, and these markers have made great contributions to the accuracy of diagnosis, therapeutic decision making, and prognosis of patients. However, heterogeneity in patient outcomes may still be observed, which highlights the insufficiency of a classification system based purely on histopathology. Great efforts have been made to incorporate new information about the molecular landscape of gliomas into novel classifications that may potentially guide treatment. In this review, we summarize three distinctive biomarkers, three most commonly altered pathways, and three classifications based on microarray data in malignant gliomas.

关键词： malignant glioma molecular biomarker IDH1 MGMT molecular classification

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光传送网中光监控通道信号Q值在线监测技术

唐勇,孙小菡,张明德,丁东

《中国工程科学》 2001年第3卷第12期页码 71-75

摘要：依据Q值与误码率（BER）的一一对应关系，提出了一种可在线监测OSC信号Q值的方案，并基于数字信号处理芯片（DSP）技术设计了监测模块，实现了OSC信号在线Q值监测。

关键词：光传送网（OTN）光监控通道（OSC）运行、管理和维护（OAM） Q值监测

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A rare case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) translocation

null

《医学前沿（英文）》 2018年第12卷第3期页码 324-329 doi: 10.1007/s11684-017-0558-z

摘要：

Splenic lymphoma with villous lymphocytes (SLVL) or splenic marginal zone lymphoma with circulating villous lymphocytes is rare, and prolymphocytic transformation of SLVL is rarer. At present, only one case of SLVL with t(8;14)(q24;q32) translocation has been reported. In this study, we report a case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) chromosome translocation that we inclined to SLVL with a prolymphocytic transformation. A 73-year-old female showed marked hepatosplenomegaly and high lymphocytosis (lymphocytes>200×10⁹/L). The abnormal lymphocytes had short coarse villi and round nuclei with prominent nucleoli. The immunophenotypes showed CD19⁺, CD20⁺, HLA-DR⁺, CD22⁺, CD5⁺, Kappa⁺, CD25^dim, CD71^dim, Lambda⁻, CD7⁻, CD10⁻, CD23⁻, CD34⁻, CD33⁻, CD13⁻, CD14⁻, CD117⁻, CD64⁻, CD103⁻, and CD11c⁻. The karyotype showed complex abnormality: 46XX,+3,−10, t(8;14)(q24;q32)[11]/46XX[⁹]. The cytoplasmic projection, immunological characteristics, and trisomy 3 chromosome abnormality supported the diagnosis of SLVL. However, the presence of prominent nucleoli and high lymphocytosis suggested prolymphocytic transformation, probably as a result of t(8,14) chromosome translocation. In this report, we described an unusual case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) translocation, which could provide help in the diagnosis and differential diagnosis of B-lymphocytic proliferative diseases.

关键词： splenic lymphoma with villous lymphocytes splenic marginal zone lymphoma transformation chromosome translocation

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Hot deformation behavior of a novel bimetal consisting of BTW1 and Q345R characterized by processing

Pengtao LIU, Lifeng MA, Weitao JIA, Tao WANG, Guanghui ZHAO

《机械工程前沿（英文）》 2019年第14卷第4期页码 489-495 doi: 10.1007/s11465-019-0554-x

摘要： Only a few studies have been conducted on the flow behavior of the novel BTW1/Q345R bimetal, which is widely used in coal equipment. In this work, compression tests were conducted on BTW1/Q345R bimetal at a temperature range of 950 °C–1200 °C and strain rates of 0.05, 0.5, 5, and 15 s by using a Gleeble-3800 thermomechanical simulator. A constitutive equation was validated by referring to the Arrhenius equation during the characterization of hot workability. The computed apparent activation energy of the BTW1/Q345R bimetal was 360 kJ/mol, and processing maps under different strain conditions were drawn. Analysis of the stress-strain relationship revealed that work hardening exerted a dominant effect on the thermal deformation of the BTW1/Q345R bimetal. The processing maps predicted that the optimal processing interval will increase with strain. Results showed that thermal deformation of the BTW1/Q345R bimetal should proceed when the temperature range varies from 1182 °C to 1200 °C and the strain rate interval is from 4.2 to 15 s .

关键词： BTW1/Q345R bimetal constitutive equation processing map work hardening

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Multiclass classification based on a deep convolutional

Ying CAI,Meng-long YANG,Jun LI

《信息与电子工程前沿（英文）》 2015年第16卷第11期页码 930-939 doi: 10.1631/FITEE.1500125

摘要： Head pose estimation has been considered an important and challenging task in computer vision. In this paper we propose a novel method to estimate head pose based on a deep convolutional neural network (DCNN) for 2D face images. We design an effective and simple method to roughly crop the face from the input image, maintaining the individual-relative facial features ratio. The method can be used in various poses. Then two convolutional neural networks are set up to train the head pose classifier and then compared with each other. The simpler one has six layers. It performs well on seven yaw poses but is somewhat unsatisfactory when mixed in two pitch poses. The other has eight layers and more pixels in input layers. It has better performance on more poses and more training samples. Before training the network, two reasonable strategies including shift and zoom are executed to prepare training samples. Finally, feature extraction filters are optimized together with the weight of the classification component through training, to minimize the classification error. Our method has been evaluated on the CAS-PEAL-R1, CMU PIE, and CUBIC FacePix databases. It has better performance than state-of-the-art methods for head pose estimation.

关键词： Head pose estimation Deep convolutional neural network Multiclass classification